Studying long non-coding RNAs in development
The Cerase Lab, previously located at the Blizard Institute, Queen Mary University of London, is now based at the Department of Biology - University of Pisa. Our team is actively engaged in researching long non-coding RNA (lncRNA) biology, with a specific focus on X Chromosome inactivation (XCI) and XCI reversal, employing various experimental approaches.
Additionally, our lab is dedicated to exploring drug discovery strategies for X-linked neurodevelopmental disorders, including Rett syndrome and CDKL5 deficiency disorder. We extend our research to female-biased neurological disorders. Our long-term plan is to delve into the epigenetic basis of brain development in both health and disease, emphasizing the roles of lncRNAs and chromatin architecture.