Andrea Cerase (Team Lead)Andrea grew up in Procida, a little island in the bay of Naples, Italy. He studied Molecular Biology at the University of Naples Federico II and worked at the Italian National Cancer Institute for his thesis. He received his MSc degree in Molecular Biology (summa cum laude) in 2002. Subsequently, he joined Prof. Maurizio D’Esposito’s group at Institute of Genetics and Biophysics (IGB-National Council of Research, CNR), Naples, studying the role of chromatin and DNA modifications in cancer - and this was the time when his interest in epigenetics began. He decided to stay in D’Esposito’s lab to do his PhD, focusing on the epigenetic mechanism of SPRY3 gene silencing in humans. As a part of his Doctoral training, Andrea came to Prof. Neil Brockdorff’s lab at the Imperial College London in 2006 as a visiting graduate student. Here he became interested in X inactivation and decided to choose this topic for his postdoc. After having his viva and receiving his PhD degree, Andrea joined the Brockdorff lab at the University of Oxford. Andrea studied the epigenetics of X chromosome inactivation, focusing on understanding how Xist mediates gene silencing. In particular, he was interested in the interplay between Xist and Polycomb Repressive Complexes. He proved that Xist and PRC2 do not interact directly, moving the balance of the much-debated Xist-mediated PRC2 recruitment model toward an indirect recruitment one. Building on this, he set up a genome-wide RNAi screen to identify novel factors involved in X chromosome inactivation and run a set of screens. Based on his pioneering system, the lab has identified important regulators of X inactivation. At the end of 2013, Andrea decided to move on with his career and returned to Italy. Back home, Andrea joined Prof. Phil Avner’s group at the EMBL-Rome as an EMBL-fellow to study the initiation phase of mouse X inactivation, particularly the role of chromatin remodelers in Xist and Tsix regulation. In 2018 Andrea started his-own laboratory at the Blizard Institute, Queen Mary University of London. His primary research focuses are epigenetics, X chromosome inactivation and lncRNAs. The Cerase Lab is currently working in X Chromosome inactivation (XCI) and XCI reversal using cell and animal models. The lab is also interested in X-linked neurodevelopmental disorders such as Rett and CDKL5 syndromes. The long-term lab plan is to study the epigenetic basis of brain development in health and disease with a particular focus on the role of lncRNAs and chromatin architecture. He is actively involved in science divulgation since his time at the University of Oxford and he regularly writes for several magazines. He is acting as an editor for many journals and as a referee for Italian, UK and international body of funding and several journals. He is an associate fellow of the Higher Education Academy (AFHEA).
Nerea Blanes-Ruis (Reserach Assistant)Nerea graduated from University of Alcalá de Henares (Madrid) in 2016 with a Bachelor of Science in Health Biology. Her undergraduate research with Dr. Ángela María Valverde focused on studying the mechanisms involved in liver fibrosis development post-BDL in a knock-out murine model for the ptp1n gene, submitting a publication in 2019. In 2018, she graduated at the Complutense University of Madrid (majors in Biochemistry, Molecular Biology and Biomedicine) and subsequently she completed her Master’s studies with Dr. Yolanda Campos González. For her master studies, she developed a protocol for the differentiation of motor neurons from human induced pluripotent cells (iPSCs) and human dermal fibroblasts as a model to study the glucose transporters 1 and 3 in Amyotrophic Lateral Sclerosis (AMLS. She is currently working as a research technician in the Cerase lab within the Genomics and Child Health Division at Blizard Institute, part of Queen Mary University of London. She is participating in several projects focused on X-chromosome inactivation (XCI) and XCI reversal using cell and animal models. In particular, she is taking part in a screening project using a double-reporter cell line to study XCI reversal in X-linked neurodevelopmental disorders such as Rett and CDKL5 syndromes.
Lorena Galiano (Lab Technician)Miss Lorna Galiano achieved her BSc in Biology from the University of Jaén, Spain in Sept. 2009. Subsequently she obtained at the University of Granada, her master degree in Regenerative Medicine (Jul. 2011). In 2015-16 she has worked as lab technician at the University College of London (UCL, UK), working on liver and digestive health. From 2017 to 2019, she worked as lab technician at the East Malling Reserach (EMR) in Kent (UK), working in plant biology. She is currently working as a research technician in the Cerase lab within the Genomics and Child Health Division at Blizard Institute, part of Queen Mary University of London.